Ryan Reynolds has expressed skepticism about Deadpool joining the Avengers or the X-Men, suggesting that such a move would signal the end of the character's journey. In a recent interview with Time, Reynolds remarked, "If Deadpool becomes an Avenger or an X-Man, we're at the end. That's wish fulfillment, and you can't give him that." This statement comes despite the massive success of Deadpool & Wolverine, where Deadpool's desire to join the Avengers is a central theme, leading many to speculate about his potential inclusion in future Marvel projects.
The cast reveal for Avengers: Doomsday last month prominently featured several veteran X-Men actors, including Kelsey Grammer, Patrick Stewart, Ian McKellen, Alan Cumming, Rebecca Romijn, and James Marsden, indicating a significant presence of the X-Men in the film. Grammer, who played Beast, made his MCU debut in The Marvels' post-credits scene, while Stewart, who portrayed Professor X, had a cameo in Doctor Strange in the Multiverse of Madness. The involvement of these actors has led to speculation that Avengers: Doomsday might be an Avengers vs. X-Men movie.
Despite the speculation, Reynolds was notably absent from the confirmed cast list for Avengers: Doomsday, while Channing Tatum, who played Gambit in Deadpool & Wolverine, was included. Reynolds hinted that a surprise cameo in a supporting role might be more fitting for Deadpool, citing the positive reception to Wesley Snipes' cameo as Blade in Deadpool & Wolverine.
As for Deadpool's future, Reynolds is currently working on a new project that he described as an "ensemble." He emphasized his preference for keeping Deadpool isolated, suggesting that the new project might feature a heavy reliance on cameos similar to Deadpool & Wolverine. Potential characters for inclusion could be Snipes' Blade, Tatum's Gambit, Jennifer Garner's Elektra, and Dafne Keen's Laura Kinney/X-23.
Deadpool & Wolverine: Easter Eggs, Cameos, and References

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Regarding Avengers: Doomsday, details remain scarce beyond the cast list. Anthony Mackie, who will reprise his role as Sam Wilson/Captain America, expressed optimism about the film, stating it would recapture the classic Marvel feeling. Other cast members like Paul Rudd (Ant-Man) and Joseph Quinn (Human Torch) have also shared their excitement. Recently, a set photo leak stirred the MCU fandom, with some fans interpreting it as a bad omen for the X-Men.
Speculation about Oscar Isaac's potential appearance as Moon Knight in Avengers: Doomsday intensified after he withdrew from a Star Wars event due to scheduling conflicts. Marvel Studios producer Kevin Feige confirmed that the Avengers: Doomsday cast reveal was not exhaustive, hinting at more surprises to come.